The office is being manned by the University Registrar, whose mandate covers all areas of administrative activities and responsible to the Vice Chancellor for the day-to-day administration of the University. The office provides support service to teaching, research, and extension activities of the University.

Directly under the Registrar are Senior Assistant Registrar (Academic Affairs), Senior Assistant Registrar (Human Resource), Senior Assistant Registrar (Public Relations), Senior Assistant Registrar (Business Development), Assistant Registrar (TaTU Hospital), and Senior Assistant Registrar (General Administration). There are other Senior Assistant Registrars, Assistant Registrars and Junior Assistant Registrars in the various Faculties and Directorates within the University who also report to the Registrar.

In the main secretariat of the Registrar he is supported by a Junior Assistant Registrar Ms. Isaaka Zaratu (MBA, BMS, and HND – Sec. & Mgt) and a Principal Administrative Assistant, Mr. Salifu Hafizu (BMS, HND – Sec. & Mgt, DBS Sec. & Mgt and Stenographer).